The effects of physiological body nutrition during the treatment of rheumatoid arthritis (RA).
Study result
The diagram shows a % decrease in the level of components C3 and C1q, as well as in the haemolytic activity of component CH50, upon completion of the nutritional intervention, calculated in relation to the values for the patients before treatment.
Tchórzewski H, Banasik M, Głowacka E, Lewkowicz P. Modyfikujący wpływ niektórych składowych oleju z wątroby rekina na odporność naturalną u ludzi. Pol Merk Lek., 2002, XIII, 76, 329
After nutritional intervention, a significant reduction was observed in the level of the components of complement C1q, C3c and CH50. The concentration levels of the components of the complement system were significantly higher in RA patients compared to the healthy individuals, which indicates that these components play a crucial role in the pathogenesis of RA. The levels of components C3 and C1q, and the haemolytic activity of component CH50 upon completion of the nutritional intervention approached the normal range.
Study result
Tchórzewski H, Banasik M, Głowacka E, Lewkowicz P. Modyfikujący wpływ niektórych składowych oleju z wątroby rekina na odporność naturalną u ludzi. Pol Merk Lek., 2002, XIII, 76, 329
RA patients were found to have decreased production of ROS by the neutrophils compared to the results obtained in healthy individuals. No statistically significant differences were obtained between the studies before and after a nutritional intervention. The pre-activation of TNF-α did not affect the generation of ROS.
Study result
The diagram indicated a % decrease in the activity of NK cells upon completion of the nutritional intervention, calculated in relation to the values for the patients before treatment.
Tchórzewski H, Banasik M, Głowacka E, Lewkowicz P. Modyfikujący wpływ niektórych składowych oleju z wątroby rekina na odporność naturalną u ludzi. Pol Merk Lek., 2002, XIII, 76, 329
The activity of the NK cells upon completion of nutritional intervention decreased by over 20%, which is desirable in the case of autoimmune diseases and results from proper self-regulation of the body.
Study description
Subjects: 10 patients with diagnosed rheumatoid arthritis (RA), not responding to their previous treatment with anti-inflammatory agents. Inclusion into the study was determined by whether a given individual met the ARA (American Rheumatism Association), encompassing:
- Morning stiffness in and around the joints, lasting for at least one hour before maximum improvement
- Oedema of soft tissues (inflammation) diagnosed by a physician within at least 3 joints
- Oedema od the proximal interphalangeal, metacarpal and carpal joints
- Symmetrical oedema
- Presence of rheumatoid nodules
- Presence of rheumatoid factor (RF)
- Presence of bone erosion visible on radiographic examination and/or osteopenia of the hand and/or wrist joints 1.
The criteria from 1 to 4 must be present for at least 6 weeks
Arnett F.C. i wsp.,The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis, Arthritis Rheum,1988, 31, 315-21.
Intervention
Standard treatment (10 mg of methotrexate per week, analgesics as needed) + nutritional intervention (3 times a day 3 capsules of BioMarine®570 containing: 120 mg of alkylglycerols, 120 mg of squalene, 25 mg of omega-3 acids, which corresponds to 18 ml of BioMarine®Medical calculated on the squalene and alkylglycerol content). The results obtained for the affected individuals were compared with the results obtained for the healthy volunteers.
The analysis encompasses the assessment of the following parameters:
- The level of complement components: C1q, C3c, C4 and the haemolytic activity of component CH50.
- The production of reactive oxygen species (ROS) by resting neutrophils (with the additional variant in which the neutrophils were pre-activated by means of TNF-α), as well as stimulated by fMLP (formylmethionyl-leucyl-phenylalanine), OZ (opsonised zymosan) and PMA (phorbol esters)
- The activity of NK cells (natural killers) defined as the cytotoxicity of NK cells (E) towards the target cells K562 (T) in the E:T proportions of 50:1, 25:1 and 12,5:1.
Tchórzewski H, Banasik M, Głowacka E, Lewkowicz P. Modyfikujący wpływ niektórych składowych oleju z wątroby rekina na odporność naturalną u ludzi. Pol Merk Lek., 2002, XIII, 76, 329
Summary – autoimmune self-regulation
Using the fish oil contained in BioMarine® supports the body in its natural immunoregulation (regulating the functioning of the immune system). One of the mechanisms behind this action is the regulation of Th lymphocyte (immune cells) activity in the Th1/Th2 system.
As a result of appropriate nutrition of the body with the building substances contained in the BioMarine® fish oil, i.e. alkylglycerols and squalene, the bone marrow starts to produce properly reacting immune cells. The activity of Th2 (anti-inflammatory) lymphocytes is reinforced. They release anti-inflammatory cytokines, such as interleukin (IL-10). This inhibits the activity of Th1 lymphocytes, which brings back the body’s equilibrium, or the so-called homeostasis.
Using the ingredients of BioMarine®, the body activates autoimmunoregulation processes which consequently alleviate the symptoms of rheumatoid arthritis.
The effectiveness of fish oils in the management of RA is also confirmed by other studies!
Why is it worth adding essential fatty acids (EFA) omega-3 to the nutritional intervention?
As demonstrated by clinical trials, using fish oils that contain essential fatty acids (EFA) EPA + DHA omega-3 (the building substances of the human body) may contribute to the elimination of inflammatory conditions in the body. These substances are already active at the level of regulating the activity of genes, thereby allowing the body to better control the reactions related to the development and cessation of inflammatory processes.
An abnormal immune response that develops in the patient leads to the formation of inflammatory reactions, which manifest themselves primarily through arthralgia (joint pain).
If the body is nourished with essential fatty acids (EFA) EPA + DHA omega-3, the synthesis of pro-inflammatory cytokines, such as PGE2, LTB4, IL-1, IL-6, TNF-α decreases, with a simultaneous increase in the production of anti-inflammatory cytokines, including IL-2 and TGFβ.
Essential fatty acids (EFA) EPA + DHA omega-3 are also transformed by the body’s cells into resolvins – RvE and RvD which strongly promote the termination of inflammatory processes. Proper nutrition of the body with essential fatty acids (EFA) EPA + DHA omega-3 leads to the eradication of inflammatory processes and alleviation of the course of RA.
Even more spectacular effects can be obtained through comprehensive action
BioMarine®Medical is a unique composition combining the potency of BioMarine®1140, BioCardine®Omega-3 and Tranu OLAVA® cod liver oil.
- Liver oil from deep-sea sharks caught in the Tasman Sea (BioMarine®)
- South Pacific Ocean sardine and anchovy muscle oil (BioCardine®Omega-3)
- Norwegian Sea cod liver oils (Tran OLAVA®)
BioMarine®Medical is also the only source of such a physiological lipid (fat) profile for the human body.
BioMarine®Medical has been created out of concern for our clients who struggle with difficult diseases on a daily basis. Its fluid form is intended to make it possible for them to take the effective dose of building and regulatory substances.
Unique composition of BioMarine®Medical
BioMarine®Medical is a unique nutritional product with such a wide range of indications – for dietary management simultaneously with the treatment of disorders in the physiological structure and function of the immune system, the haematopoietic system, the lymphatic system, the anti-inflammatory system, the liver and the bone marrow, the brain and the nervous system, the heart and the circulatory system, the eyes and the skin, the mucous membranes and the endothelium, as well as their consequences, including infections, cancers, RA, psoriasis, allergies, schizophrenia, and coronary heart disease.
The content of all building and regulatory lipids in BioMarine®Medical 5 ml of the liquid):
Special-purpose medical food should ALWAYS be noted down on a prescription
The immune system, the anti-inflammatory system, the hematopoietic system and the cell renewal system will be fully effective (physiologically) when they receive a scientifically engineered dose of BioMarine®Medical.
Dosage table
Unless your doctor or nutrition specialist recommends otherwise, BioMarine®Medical should be used as follows:
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In parallel with the treatment of diseases in the acute phase:: cancer, infection, RA, psoriasis, recent stroke and heart attack, schizophrenia and depression, |
FOR ADULTS: |
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FOR CHILDREN: |
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In parallel with the treatment of diseases in the chronic phase: cancer, RA, psoriasis, schizophrenia and depression, post infections and coronary events |
FOR ADULTS AND CHILDREN: |
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In parallel with the diagnosis of disorders or diseases of: bone marrow and immune and hematopoietic systems, brain and nervous system, heart and circulatory system and inflammatory diseases |
FOR ADULTS AND CHILDREN: |
Based on the dosage table above, calculate what dose of BioMarine®Medical is currently needed by your body.
BioMarine®Medical should be taken 15-20 minutes before meal – this will ensure optimum absorption of the lipids contained in the product.
The daily dose of the product is usually taken in 2-3 portions. However, if you take greater amounts of BioMarine®Medical, you may divide your daily dose into more portions (even up to 8). An ideal solution is to use the product before each meal.
Fish oil is absorbed already through the oral mucosa. Therefore, before swallowing, it should be kept for a few seconds in the mouth – this way, the mucous membranes undergo direct physiological reconstruction and regeneration.
If the fish aftertaste is hard to accept, you may mix a portion of the oil with natural fruit juice (e.g. raspberry or cherry, but never with citrus fruits), eat is together with bread, or swallow with a small amount of boiled water or herbal tea.
Source of the effect
The effects arising out of using BioCardine®Omega-3 and BioMarine® are produced physiologically by the body. This means that they cannot be achieved in any other way. For their production, the body needs to activate concrete physiological processes that require relevant substances. And hence the resulting effects are so significant and multi-directional. This translates into significantly greater strength of the body as well as better effectiveness in saving patients’ life and health.
Rheumatoid Arthritis (RA) – what it is?
Rheumatoid arthritis (RA) is a chronic inflammatory condition affecting the joints and various organs. The characteristic symptoms of this disease include pain, stiffness and oedema of the joints in the hands and feet. If the inflammatory condition is chronic and untreated, the joints become damaged.
This disease also causes damage to many organs and systems (including the kidney and the circulatory system). In extreme cases, it may even lead to premature death.
Etiology of the disease
The diseases stems from an inflammatory process which begins inside a joint. The frequent cause behind such a situation is the improper functioning of the immune system. This means that the immune system produces antibodies against its own tissues (i.e. destroys itself) – in this case, in the area of the joint capsule.
The causes of RA may be manifold and they have not been fully identified. Irrespective of the cause, the effect is still the same: an improperly functioning body and its most important defence and regeneration systems. Improper structure of the body, especially the immune and anti-inflammatory systems, prevents it from functioning in a physiological manner. Cell membranes are oversaturated with compounds from which the body produces excessive amounts of pro-inflammatory substances. It is the prolonged inflammatory condition that, amongst others, leads to RA.
lek. Zofia Guła, dr med. Mariusz Korkosz, „Reumatoidalne zapalenie stawów”, www.mp.pl
Share of the complement system
The complement system is a complex system of proteins which primarily occur in the plasma, but also in other fluids of the body, as well as the system of related receptors.
These proteins primarily participate in the innate, non-specific immune mechanisms. In the course of an immune response and inflammatory reaction, the body activates a system of these proteins, which results in:
- mutated, damaged or pathogen-infected cell lysis;
- psonisation (“marking”) of pathogens, thereby making them more effectively identifiable by the immune system;
- increased activity of phagocytes (cells “absorbing” pathogens);
- a more effective course of the inflammatory reaction.
The elements of the complement system are marked with letters C and numbered from 1 to 9. The marking system also incorporates small letters (a, b, and c), thereby making it possible to better describe the particular stages of the activation.
The reaction with the participation of the complement system may be activated both in the presence of antibodies (the classic and lectin pathway of activation) or without them (the alternative activation pathway). The activation process is of a cascading nature: this means that each activated component stimulates another one. In the course of all the activation pathways of the complement system, the key role is played by two enzymes, namely C3 convertase and C5 convertase, which lead to the activation of the following proteins C3a, C3b, C5a and C5b. The activity of these two enzymes strongly reinforces the functioning of the entire protein complex.
Regardless of the activation method, the final element is the formation of the membrane-attacking complex (MAC), which leads to increased permeability of membranes in the target cells. Such opening (channels) allow for the outflow of components essential for cell functioning (ions, ATP, nutrients), and – at the same time – make the cell accessible for bactericidal and bacteriostatic factors, as well as drugs.
The entire system is supervised by a network of regulatory factors. Its excessive stimulation or defects in the regulatory proteins are the cause of pathological states (e.g. autoimmune diseases). Similarly, an insufficient activity or deficiencies of the particular components may result in decreased immunity of the body.
CH50 is an analytical method allowing for the assessment of the standard activation pathway of the complement. The test determines the serum haemolytic activity by establishing the serum concentration level at which the lysis of 50% of the standardised cell suspension is activated.
The reduction of the parameters related to the complement system activity in patients with autoimmune diseases (such as RA) is desirable. It reflects the autoimmunoregulation processes activated by the body, striving to obtain the values of given parameters typical of healthy individuals.
Statistics
In developed countries, rheumatoid arthritis affects 1 out of 100 individuals, with three times more women than men. The disease usually manifests itself between the age of 30 and 50 years in women (although it may occur both earlier and later), whereas the incidence rate in men increases with age. In most patients, RA develops insidiously. The first symptoms are non-specific (weakness, subfebrile state, muscle pain, loss of appetite, reduced body weight) and usually precede the articular symptoms.
lek. Zofia Guła, dr med. Mariusz Korkosz, “Rheumatoid arthritis”, www.mp.pl
Opinions
Ever since I started using BioMarine®570, the pain in my joints and bones has been reduced. I am also within the first cytological group (previously I was always within the second group). Generally, I feel better and I probably cannot imagine living without BioMarine®. I honestly recommend it. Dose: 4 BioMarine®570
Beata, Legionowo
I started using BioMarine®570 soon after I was diagnosed with RA. The intensity of pain in the joints was reduced as soon as after 3 months of using the product. I have been using it for 3 years on and off. The daily dose is 3 capsules. I will keep using the product. Dose: 3 caps. BioMarine®570 / day
Lucyna, Giżycko
Dear specialist, in treating chronic diseases you need the help of experts in the genetic and physiological nutrition of the body.
The experts of the Science, Research and Development Department at MARINEX International are highly qualified specialists with many years of experience. They enjoy an enormous amount of trust amongst their clients, because they take care of their health every day. All this specialist knowledge can be obtained here absolutely for free.
Physiologist,
dr n. biol. Joanna Zielińska – Tomaszewska
Pharmacist, environmental contamination diagnostician,
dr n. biol. Barbara Bukowska
Physiologist, licences dietician
mgr Konrad Tomaszewski
Please feel invited to book your consultations from Monday to Friday between 7:00 am and 2:30 pm.
Literature
- lek. Zofia Guła, dr med. Mariusz Korkosz „Rheumatoid arthritis” Mp.pl
Zobacz także:
Infections
Coronary disease
Cancer
Psoriasis
Allergy
Schizophrenia
Studies
Dosage calculators
I use BioMarine®570 because I suffer from rheumatism which destroys my joints and the steroids I also use lead to osteoporosis. That is why I have been taking 2 capsules of BioMarine®570 daily since May 2014. My bones have become stronger. BioMarine®570 is effective in preventing osteoporosis. That is why I take it every day and I am going to continue the therapy.
Urszula, Działdowo